The objective of this study was to evaluate the efficacy and complication of the treatment of pelvic external combined with 252-Cf neutron intracavitary radiotherapy with or without platinum in local advanced cervical cancer patients in the short and long term.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
200
Chemotherapy: Nedaplatin(NDP) 30-40mg/m2 iv., on day1, 4weeks as one cycle
patients received 20 Gy2.0/f, for 25-27f (SSD)with 8mv-X rays (SSD)
total dose of reference point A was 4400cGy, in four times Transvaginal implant sessions during Pelvic External Radiations
Daping Hospital and the Research Institute of Surgery of the Third Military Medical University
Chongqing, China
RECRUITINGAcute toxicity events
chemo-related toxicity as measured by CTCAE v. 4.0, radiation-related toxicity as measured by RTOG/EORTC criteria
Time frame: Week 5 of Radiation Therapy (RT)
Long-trem toxicity events
chemo-related toxicity as measured by CTCAE v. 4.0, radiation-related toxicity as measured by RTOG/EORTC criteria
Time frame: through study completion, an average of 5 year
2 Years Overall survial Rate
chemo-related toxicity as measured by CTCAE v. 4.0, radiation-related toxicity
Time frame: 2 years
3 Years Overall survial Rate
Time frame: 3 years
5 Years Overall survial Rate
Time frame: 5 years
Disease-free survival (DFS)
Time frame: through study completion, an average of 3 year
Overall survial (OS)
Time frame: through study completion, an average of 5 year
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