The purpose of this study is to evaluate safety and efficacy of three main perfusion methods in surgical repair of coarctation of aorta with aortic arch hypoplasia in infants.
Three perfusion techniques of visceral protection will be assessed - deep hypothermic circulatory arrest, selective antegrade cerebral perfusion and double arterial cannulation (perfusion of brachiocephalic artery with thoracic descending aorta by two arterial cannulas)
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
45
Surgical repair of coarctation of aorta with aortic arch hypoplasia under CPB
State Research Institute of CIrculation Pathology Novosibirsk, Russian Federation
Novosibirsk, Russia
RECRUITINGAdverse events in early postoperative period
Number of participants with adverse events that are related to treatment (including hospital mortality, renal injury (pRIFLE criteria), neurological complications (confirmed by CT or MRI) )
Time frame: 30 days after surgery
Degree of inotropic support (inotropic score)
Time frame: through ICU stay, an average of 3 weeks
Intraoperative blood loss (ml)
Time frame: intraoperatively
Temperature of cooling (C)
Time frame: intraoperatively
Duration of CPB (min)
Time frame: intraoperatively
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