Effect of Rifampicin on the Pharmacokinetics of Apatinib

Inclusion Criteria: * female of non-childbearing potential or male; * age 18-45 years; * body mass index 19-24 kg/m2 with total body weight; Exclusion Criteria: * clinically significant medical or surgical conditions with the potential to interfere with the absorption, distribution, metabolism or excretion of the study drugs; * history of alcohol abuse; smoker; * electrocardiogram(ECG) abnormality; * blood pressure \>140/90 mmHg; * treatment with an investigational drug or any known CYP450 enzyme inducing/-inhibiting agents or herbal supplements within 14 days prior to first dose of study medication; * Subjects were to abstain from using prescription and non-prescription drugs (other than acetaminophen as deemed necessary), vitamins and dietary supplements within 14 days prior to the first dose of study medication and throughout the study.