Prevention of Periprosthetic Bone Loss After Total Hip Replacement by Annual Bisphosphonate Therapy

Inclusion Criteria: 1. Male or female,between 35 and 85 years of age 2. Indicated for Total hip replacement for various hip diseases 3. Has preoperative DXA study within 3 months before the total hip replacement procedure or willing to receive preoperative DXA study as a baseline comparison 4. Signed written informed consent 5. Standard transgluteal approach for total hip replacement using Zimmer Triology Cup and Versys Fiber Metal Taper Stem with metal to highly cross-linked polyethylene bearing surface Exclusion Criteria: 1. Any prior use of intravenous bisphosphonate within the last 2 years 2. Uncontrolled seizure disorders associated with falls 3. A history of invasive malignancy of any organ system, treated or untreated, within the past five years; excluding, basal cell or squamous cell carcinoma of the skin, colonic polyps with non-invasive malignancy which have been removed 4. Carcinoma in situ of the uterine cervix 5. History of osteogenesis imperfecta, multiple myeloma, or Paget's disease 6. Active primary hyperparathyroidism 7. History of iritis or uveitis 8. Self-reported history of diabetic nephropathy or retinopathy 9. AST or ALT more than twice the upper limit of normal 10. Alkaline phosphatase more than twice the upper limit of normal 11. Serum calcium 2.75 mmol/L (11.0 mg/dL) 12. Baseline renal insufficiency (calculated creatinine clearance 35 ml/min) 13. History of hypersensitivity to bisphosphonates 14. Use of any investigational drug(s) and/or devices within 30 days prior to randomization 15. Any medical or psychiatric condition which, in the Investigator's opinion, would preclude the participant from adhering to the Protocol or completing the trial per protocol 16. Use of hip protectors 17. With implant or prosthesis on the contralateral hip joint