Development of a New Neuroimaging Method Aimed to Differentiate Mnesic Abilities of Alzheimer and Depressed Patients

Centre Hospitalier Universitaire de Besancon30 enrolled

Overview

The purpose of this study is to use a new method to differentiate mnesic abilities of early alzheimer patients and patients with a depressive disorder. This method is based on the recording of cerebral activity while patients listen to familiar, unfamiliar and newly-learned music.

Study Type

INTERVENTIONAL

Allocation

NON_RANDOMIZED

Purpose

DIAGNOSTIC

Masking

NONE

Enrollment

Conditions

Alzheimer Disease Depression

Interventions

high-density electroencephalographyDEVICE

Musical stimulation during electroencephalography recording

Eligibility

Sex: ALLMin age: 60 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Being right-handed * recorded consent * For Alzheimer patients: Mini Mental Status Examination (MMSE) score \>= 18 * For patients with a depressive disorder : Major Depressive Disorder according to Diagnostic and Statistical Manual of Mental Disorders (DSM IV) and Montgomery-Asberg depression rating scale (MADRS) score \>= 25 * For healthy controls : no cognitive deficit, MADRS score \< 25, no depressive disorder according to DSM IV Exclusion Criteria: * Auditory deficit * contraindication to a high-density electroencephalography exam * refusal to participate in the study

Locations (1)

CHRU Besançon

Besançon, Franche-Comte, France

RECRUITING

Outcomes

Primary Outcomes

Amplitude of event-related potentials

Measurements of the amplitude of event-related potentials with electroencephalography at day one for familiar and unfamiliar songs and after 2 weeks for newly learned songs

Time frame: day 1 for familiar and unfamiliar songs and day 14 for newly learned songs

Secondary Outcomes

Spectral power

Measurements of the spectral power with electroencephalography at day one for familiar and unfamiliar songs and after 2 weeks for newly learned songs

Time frame: day 1 for familiar and unfamiliar songs and day 14 for newly learned songs

Central Contacts

Damien Gabriel, PhD

CONTACT

0033381219148 dgabriel@chu-besancon.fr

Magali Nicolier, PhD

CONTACT

0033381219007 mnicolier@chu-besancon.fr

Data from ClinicalTrials.gov

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