Repetitive Transcranial Magnetic Stimulation for the Treatment of the Tardive Dyskinesia.

Shanghai Mental Health Center60 enrolled

Overview

The purpose of this study is to explore the therapeutic effect and mechanism of transcranial magnetic stimulation (rTMS) in the treatment of the tardive dyskinesia.

The study was a parallel control design trial for 2 weeks. Patients with schizophrenia were treated with 10-Hz rTMS on left motor cortex (added to the ongoing treatment). Clinical symptoms and MEP were assessment before and after rTMS treatment.

Study Type

INTERVENTIONAL

Allocation

NON_RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

Tardive Dyskinesia

Interventions

Repetitive Transcranial Magnetic StimulationDEVICE

Stimulate the primary motor cortex for 2 weeks.

Eligibility

Sex: ALLMin age: 18 YearsMax age: 65 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * The diagnosis of schizophrenia according to DSM-IV； * At least two item of Abnormal Involuntary Movement Scale（AIMS） must be 2 points or higher * these symptoms are not from Parkinson，tourette's syndrome,huntington disease * Signed an informed consent Exclusion Criteria: * rTMS contraindications: intracranial metal substance, with heart pacemakers and cochlear implants, intracranial pressure * patients to be diagnosed according to DSM-IV for substance abused, development delayed * current treatment with anticonvulsant acting drugs such as anticonvulsants, benzodiazepines * Acute risk of suicide and impulse * history of epileptic seizures or the presence of epileptic activity documented on the basis of EEG * pregnant and lactant women

Locations (1)

Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine

Shanghai, Shanghai Municipality, China

RECRUITING