Efficacy Study Between Two Different Dosages of an Antiparasitic in Patients With Crusted Scabies

Inclusion Criteria: Patients ≥ 18 years old, diagnosed with severe forms of scabies 1. clinical criteria : cutaneous lesions of scabies * crusted scabies: at least two sites of hyperkeratosis will define crusted scabies and/or * profuse scabies : spreading lesions with erythematous scaly eruption of the neck, face or trunk without hyperkeratosis 2. paraclinical criteria: * Positive parasitological test * and/or dermoscopic exam with signs of scabies Effective contraception for women in age of pregnancy Written consent from patient or his/her legal representant, trustworthy person or family member Affiliated to a social security scheme Exclusion Criteria: * Pregnant and/or breastfeeding women * Intolerance to ivermectin or topical treatment (permethrin 5% cream) or emollient cream * Use of anti parasitic drug (ivermectin or albendazole) within the past 7 days * Abnormal liver test results: ALT and/or AST \>3N within the past 7 days (within 6 months if no hepatic history) * Participation in other biomedical drug research * Patient deprived of freedom * Any psychological, familial, sociological or geographical condition potentially hampering compliance with the study protocol and follow-up schedule