Genetic Susceptibility Factors for Candidemia.

University Hospital, Lille453 enrolled

Overview

This is a prospective case-control physiopathological study, which main objective is to determine the genetic host factors predisposing to candidemia. Secondary objectives are to develop new diagnosis tools using the biological collection, to describe and update epidemiology, to analyse the influence of genetic polymorphisms on prognosis.

Study Type

OBSERVATIONAL

Enrollment

453

Conditions

Invasive Candidiasis Candidemia Genetic Predisposition to Disease

Interventions

Analysis of genetic polymorphismsGENETIC

An analysis of the SNPs (single nucleotide polymorphism) of 25 candidate genes will be performed. This analysis will be completed by a genome wide association study.

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Patient older than 18 years. * Informed consent. * Positive blood culture with isolation of Candida sp. Exclusion Criteria: * No informed consent. * Patient younger than 18. * No insurance coverage.

Locations (1)

Hôpital Salengro, Intensive care departement, CHRU

Lille, France

Outcomes

Primary Outcomes

Frequency of the polymorphisms between the groups

Time frame: In the 48-72 hours following the positive blood culture

Data from ClinicalTrials.gov

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