The Response Evaluation Criteria in Solid Tumors (RECIST), based on differences in tumor size, has been considered as a reproducible method that facilitates not only the measurement of the mass but the evaluation of response to given treatments; while classic chemotherapy induces a reduction of the tumor, new target therapies frequently produce the stabilization of the disease or a delayed progression. These new therapeutic alternatives have shade light on the limitations of the RECIST criteria, since the response to these type of treatments are basically associated with changes on the radiological characteristics of the tumor, as well as other findings in functional imaging. This study is aimed to compare the response rates according both Choi and RECIST criteria.
Study Type
OBSERVATIONAL
Enrollment
104
Hospital Universitario Marqués de Valdecilla
Santander, Cantabria, Spain
Hospital Universitari Vall d'Hebron
Barcelona, Spain
Hospital Universitario 12 de Octubre
Madrid, Spain
Hospital Universitario La Paz
Madrid, Spain
Hospital Universitario Ramón y Cajal
Madrid, Spain
Hospital Universitario Morales Meseguer
Murcia, Spain
Hospital Universitario Central de Asturias
Oviedo, Spain
Complejo Hospitalario de Navarra
Pamplona, Spain
Hospital Universitario Virgen del Rocio
Seville, Spain
Hospital Universitario Miguel Servet
Zaragoza, Spain
Response to treatment
According Choi and RECIST Criteria
Time frame: 3 months
Progression Free Survival on partial response
Time between start of treatment and progression of disease in patients with partial response
Time frame: 3 months
Progression Free Survival on Stable Disease
Time between start of treatment and progression of disease in patients with stable disease
Time frame: 3 months
Impact of Tumor Uptake on Response to Treatment
Description of the uptake of pancreatic neuroendocrine tumor lesions in the arterial phase (baseline evaluation), and assessment of a possible correlation with the response to treatment using the RECIST criteria.
Time frame: 3 months
Impact of Response to Treatment and Progression Free Survival
Description of the uptake of pancreatic neuroendocrine tumor lesions in the arterial phase and assess ment of a possible correlation with the progression free survival.
Time frame: 3 months
Impact of Choi criteria and Progression of Disease
Correlation of Changes on the uptake of pancreatic neuroendocrine tumor lesions in the arterial phase and progression of disease.
Time frame: 3 months
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