Safety and Efficacy of Intra-Arterial and Intra-Tumoral Ad-p53 With Capecitabine (Xeloda) or Anti-PD-1 in Liver Metastases of Solid Tumors and Recurrent Head and Neck Squamous Cell Cancer

Inclusion Criteria: 1. Signed informed consent 2. Male or female, age 18 or above, who agree to use barrier contraception throughout the study. Females of child-bearing potential must be non-pregnant and non-lactating throughout the study. 3. Histologically or cytologically confirmed solid tumors or hepatocellular carcinoma with known disease progression. 4. Each patient entered on the study must have disease that is evaluable for response using RECIST 1.1 criteria with a minimum size of 1 cm by CT/MRI or physical examination 5. Carcinoma patients in Arm A or Arm B must have received at least 1 prior regimen of standard of care systemic antitumor therapy for their metastatic disease and experienced tumor progression within 3 months after the last prior administration of the therapy or experienced unacceptable toxicity to these treatments. 6. Subjects in Arm A and Arm B should have measurable CT evidence of liver metastases or liver lesions that are not treatable by surgical resection or local ablation in consultation with hepatobiliary specialist. 7. The maximum tumor diameters for each Cohort for both Arm A and Arm B should achieve a dose of approximately 1x1011 viral particles (vp)/cm3 of tumor volume. (see Table 1). Please refer to Table for calculating tumor volume. 8. ECOG Performance Status 0 - 1 9. Either no brain metastases or irradiated stable brain metastases 10. Life expectancy at least 3 months 11. No prior autologous or allogeneic organ or tissue transplantation 12. PT/international normalized ratio (INR) ≤ULN; aPTT ≤ULN. 13. ANC ≥1500 cells/mm3 14. Platelet count ≥100,000 cells/mm3 15. Hemoglobin ≥9.0 g/dL 16. Creatinine \<2.0 mg/dL or creatinine clearance ≥50 mL/min 17. Total bilirubin \<1.5 x ULN 18. AST and ALT \<3.0 x ULN 19. Alkaline phosphatase ≤5 x ULN 20. Negative pregnancy test in women of childbearing potential 21. Fertile patients must use effective contraception 22. No non-approved investigational agents or procedures ≤4 weeks of study entry 23. Patients with PRIMARY HEPATIC CANCER must have an undetectable viral load for Hepatitis B and C. 24. Patients with Primary Hepatic Cancer have not recently been treated with antivirals. 25. Troponin blood level within normal limits. 26. Favorable biomarker profile defined by either wild type p53 gene sequence or less than 20% p53 positive tumor cells by immunohistochemistry 27. Echocardiogram with normal ejection fractions 28. Normal lung oxygen saturation by pulse oximeter, as determined by the Principal Investigator based on patient history and status. 29. Arm C patients must have loco-regional recurrent head and neck squamous cell carcinoma (HNSCC), excluding endolaryngeal recurrence, meeting the following criteria: * Tumor progression within 6 months of platinum-based chemotherapy * All HNSCC lesions should be in the head and neck region and suitable for intra-tumoral injection * The total sum of Ad-p53 Injection Doses (mL) based upon the tumor volumes shown in Table 2 should be less than or equal to 25 mL as the MTD of Ad-p53 is 2.5 x1013 vp/treatment day. Exclusion Criteria 1. Subjects must not be candidates for hepatic surgery or locoregional therapy of liver tumors with curative intent. 2. Liver tumors must not be estimated to invade approximately more than one-third of the liver. 3. Liver tumor-directed therapy, hepatic surgery, antibody-based therapy, or immunotherapy must not have been performed \< 28 days, chemotherapy \< 21 days, and targeted small molecule therapy or hormonal therapy \< 14 days prior to enrollment. No radiation to tumor sites during the last 4 weeks. 4. No macroscopic intra-vascular invasion by tumors of the main portal vein, hepatic vein or vena cava. 5. Chronic liver dysfunction prior to development of liver metastases (Child-Pugh C or greater). 6. Active alcohol dependence 7. Prior radiation performed to areas of measurable disease ≤ four weeks of study entry unless there is documented evidence of disease progression. 8. Use of systemic anti-cancer therapy ≤ 4 weeks, or six weeks if the systemic therapy contains a nitrosourea or mitomycin C. 9. Neuropathy (≥grade 2 CTCAE) 10. History of allergic reactions to any components of the treatments 11. Prior additional malignancy within 2 years except for non-melanoma skin cancer, carcinoma in situ of the breast, oral cavity or cervix. 12. Severe, active comorbidity, including any of the following: 1. Active clinically serious infection requiring intravenous antibiotics at the time of study entry (CTCAE Grade 2) 2. Hepatic insufficiency not due to tumor resulting in clinical jaundice or bilirubin \>1.5 x ULN and/or coagulation defects 3. Thrombotic or embolic event within the last 6 months including portal vein thrombosis 4. Must not require concomitant treatment with anticoagulants 5. QTcb \>470 ms 6. Bleeding or evidence or history of clinically significant bleeding diathesis or coagulopathy within the last 3 months 7. Uncontrolled hypertension on anti-hypertensive medication (systolic blood pressure \>150 mmHg or diastolic blood pressure \>95 mmHg) 8. Must not have been diagnosed with autoimmune disease or be immunosuppressed 9. Patients with non-hepatocellular carcinoma must not have acute or chronic hepatitis B or hepatitis C infection 10. Known significant immunodeficiency due to underlying illness (e.g. HIV/AIDS) and/or immunosuppressive medication including high-dose corticosteroids. 11. Severe bleeding, hemoptysis, gastrointestinal hemorrhage, CNS bleeding, clinically significant hemorrhage or vaginal bleeding during the last 6 months 12. Subjects must not have evidence of pneumonitis or inflammatory lung disease on CT scan and x-ray 13. Chronic treatment for more than 6 months with systemic corticosteroids at doses above 10 mg prednisolone or equivalent before study entry 14. Psychological, familial, sociological or geographical or other condition which in the opinion of the investigator would not permit study follow-up or other compliance with the study protocol. 15. Subjects must not have tumors adjacent to vital structures such as carotid arteries.