The purpose of this study is to assess the efficacy of dexmedetomidine on lung protection in patient with sepsis undergoing cleaning focus of infection.
Sepsis is one of the most common, life-threatening medical conditions and is frequently complicated by organ failures, especially lung injury. It is well accepted that inflammatory reaction is the major cause of lung injury. Dexmedetomidine (Dex) is a novel α2-adrenoceptor agonist that is primarily used in surgical anesthesia and conscious-sedation. Recently, animal studies have shown that Dex plays an anti-inflammatory role, while it is not known whether Dex possesses any lung protective functions in patients with sepsis. Therefore, the aim of this study is to investigate the efficacy of Dex on lung protection in patient with sepsis undergoing cleaning focus of infection.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
DOUBLE
Enrollment
50
receive a loading infusion of dexmedetomidine (1ug/kg) for 10min follow by a maintenance infusion (0.5ug/kg·h) continued until the end of the surgery
receive matching placebo (equal volume of normal saline)
General Hospital of Ningxia Medical University
Yinchuan, Ningxia, China
The Alveolar-Arterial Oxygen Difference
Arterial blood samples were sampled before anesthesia for the alveolar-arterial oxygen difference by using blood gas analyzer.
Time frame: Before anesthesia
The Oxygenation Index
Arterial blood samples were sampled before anesthesia for the oxygenation index by using blood gas analyzer.
Time frame: Before anesthesia
The Respiratory Index
Arterial blood samples were sampled before anesthesia for the respiratory index by using blood gas analyzer.
Time frame: Before anesthesia
The Alveolar-Arterial Oxygen Difference
Arterial blood samples were sampled at 3 minutes after the skin is sutured for the alveolar-arterial oxygen difference by using blood gas analyzer.
Time frame: At 3 minutes after the skin is sutured
The Oxygenation Index
Arterial blood samples were sampled at 3 minutes after the skin is sutured for the oxygenation index by using blood gas analyzer.
Time frame: At 3 minutes after the skin is sutured
The Respiratory Index
Arterial blood samples were sampled at 3 minutes after the skin is sutured for the respiratory index by using blood gas analyzer.
Time frame: At 3 minutes after the skin is sutured
Change of tumor necrosis factor-α before anesthesia and after dexmedetomidine or placebo infusion instantly
Blood samples were sampled before anesthesia and at 3 minutes after the skin is sutured for the serum tumor necrosis factor-α，which were analyzed by using enzyme linked immunosorbent assay (ELISA).
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Time frame: Before anesthesia and at 3 minutes after the skin is sutured
Change of interleukin-1β before anesthesia and after dexmedetomidine or placebo infusion instantly
Blood samples were sampled before anesthesia and at 3 minutes after the skin is sutured for the interleukin-1β，which were analyzed by using enzyme linked immunosorbent assay (ELISA).
Time frame: Before anesthesia and at 3 minutes after the skin is sutured
Change of the lactic acid before anesthesia and after dexmedetomidine or placebo infusion instantly
Arterial blood samples were sampled before anesthesia and at 3 minutes after the skin is sutured for the lactic acid by using blood gas analyzer.
Time frame: Before anesthesia and at 3 minutes after the skin is sutured