Effects of Dexmedetomidine on Oxygenation and Lung Mechanics in Morbidly Obese Patients Undergoing Bariatric Operations

Cairo University42 enrolled

Overview

The study aims to investigate the effect of dexmedetomidine on oxygenation and lung mechanics in morbidly obese patients

The patients of interest are morbid obese patients scheduled for bariatric surgery. Dexmeditomidine will be infused intraoperatively after induction of anesthesia. lung mechanics (dead space and compliance) as well as oxygenation (PF ratio) will be monitored intraoperatively and postoperatively

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

QUADRUPLE

Enrollment

Conditions

Restrictive Lung Disease

Interventions

DexmedetomidineDRUG

Dexmedetomidine infusion was previously reported to improve oxygenation and lung dynamics in patients with obstructive lung diseases. In our study we are going to investigate its effect on oxygenation and lung dynamics in restrictive lung disease

Normal salineDRUG

Normal saline

Eligibility

Sex: ALLMin age: 18 YearsMax age: 65 Years

Medical Language ↔ Plain English

Inclusion Criteria: \- Morbid obese (body mass index \> 40) with documented restrictive lung disease scheduled to bariatric operation. Exclusion Criteria: * Heart failure * ِِِِArrhythmia * Heart block * Severe liver or kidney impairment.

Locations (1)

Cairo University

Cairo, Egypt

Outcomes

Primary Outcomes

Oxygenation

assessed by P/F ratio

Time frame: 2 hours

Secondary Outcomes

Lung mechanics

lung compliance and dead space

Time frame: 2 hours

arterial blood pressure

arterial blood pressure measured in mmHg

Time frame: 2 hours

plateau airway pressure

plateau airway pressure measured in cmH2o

Time frame: 2 hours

heart rate

number of heart beats per minute

Time frame: 2 hours

Data from ClinicalTrials.gov

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