Cognitive, Morphological and Neurobiological Progressive Aspects in Bipolar Disorders in the Elderly: Toward to a Neurodegenerescence Detection?

Inclusion Criteria: * male or female subject aged between 60 and 80 years old * in patient or out-patient at one of the centers participating in the study * Mini-mental state examination (MMSE) score \> 20 at baseline * patient with diagnostic of amnestic-Mild Cognitive Impairment * patients suffering of bipolar disorders type I or II * in remitted (euthymic) state at baseline Exclusion Criteria: * pre-existing history of dementia * history of neurologic disorder * lifetime history of a severe psychiatric disorder other than bipolar disorders * current medical problems * patients treated with electroconvulsive therapy within the past six months * patients with substance abuse or dependence within the past 12 months * patients hospitalized without consent