Validation of a Portable Medical Device for Diagnostic in Vitro

Inclusion Criteria of healthy volunteers: * Man or woman between 18 and 70 years * Body Mass Index \>18 and \<29 * Absence of any acute pathology in the month preceding the study * To be affiliated or beneficiary of social security Exclusion Criteria of healthy volunteers: * Pregnant, partutient or breastfeeding woman * Patient with Raynaud's syndrome * Person deprived of liberty by legal or administrative decision, person to a legal protection order * Deferral periods for other clinical studies * Annual threshold compensation attain for biomedical search participations Inclusion Criteria of patients: * Man or woman between 18 and 80 years * Patient treated by oral anti vitamin K anticoagulants (coumadine, warfarine, fluidione) * Absence of any acute pathology in the month preceding the study * To be affiliated or beneficiary of social security Exclusion Criteria of healthy patients: * Pregnant, partutient or breastfeeding woman * Patient with Raynaud's syndrome * Person deprived of liberty by legal or administrative decision, person to a legal protection order * Deferral periods for other clinical studies * Annual threshold compensation attain for biomedical search participations