Bipolar disorder is a chronic and frequent mood pathology, that impacts on emotional and socio-professional life of sick subjects, and also increase mortality by suicide. Suicide is considered as a bipolar disorder result. The main goal of this study is the endophenotype characterization from a clinical and cognitive point of view, of a bipolar spectrum's disorder present in a family, and then highlight a mutation of one of the genes involved is this disorder.
Heritability of bipolar disorder is now well established, but seems to be multifactorial in most of the cases. The use of an endophenotype characterized in a family presenting numerous bipolar sufferers enable to reflect the expression of simpler genetic variants than those involved in the disease, and might enable the identification of genes involved in the etiopathogenesis of this endophenotype.
Study Type
INTERVENTIONAL
Allocation
NA
Masking
NONE
Enrollment
29
Draw an endophenotype and genetic study
UniversityHospitalGrenoble
La Tronche, France
RECRUITINGNeuropsychological evaluations tests
Neuropsychological evaluations (about one hour) : TMT (Trail Making Test) A and B, Stroop VFT (Visual Field Testing), DST (Dyslexia Screening Test) Tower of London test Hayling, CPT (continuous performance task) CVLT (California Verbal Learning Test) tests.
Time frame: One day
Eye tracking.
The volunteer will follow an instruction according to the color seen on a screen. This instruction is to look at the side where there is a flashlight and to look at the opopsite if the light is unbroken. Mistakes will be count.
Time frame: One hour
Blood sampling
Genetic sample for extraction of DNA.
Time frame: 3 minutes
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.