Ad-HGF Treatment for Myocardial Infarction

Inclusion Criteria: * Male or female 18-80 years of age * Clinical diagnosis of anterior ST-segment elevation myocardial infarction (STEMI) within the last 30 days, with any one of the following 12-lead electrocardiographic changes: * a) Greater than or equal to 2 mm ST-segment elevation) in 2 adjacent electrocardiographic precordial leads * b) A new left bundle branch block AND and an increase in cardiospecific enzymes \>3x CK, or increase in troponin compared to institution laboratory normal ranges * Successful PCI with stent implantation to infarct-related artery within the last 30 days; defined as residual stenosis no greater than 30%, Thrombolysis In Myocardial Infarction (TIMI) flow of at least 2 and a reference diameter of at least \> 2mm * Is considered hemodynamically stable at time of enrollment and immediately prior to Ad-HGF delivery * Screening LVEF for the first 12 enrolled participants, must be no greater than 40% by echocardiography (determined by Simpson's method) performed at least 2 days after revascularization procedure. Subsequent participants enrolled in the trial, must have an LVEF no greater than 45%. (All screening echos done within the first 4 days post percutaneous coronary intervention (PCI) must be repeated either by echocardiography or MRI prior to Ad-HGF delivery to ensure that the variability does not exceed 10%) * In the case of a previous myocardial infarction, documented LVEF must be 50% or greater * Female participants must be surgically sterile, post-menopausal, have documented infertility, or are of child-bearing potential wih laboratory confirmation of non-pregnant state * Provided written informed consent and is willing to comply with study follow-up visits Exclusion Criteria: * Significant unprotected left main disease (stenosis of 50% or greater)on diagnostic angiography * An increase in LVEF by greater that 10% from initial LVEF evaluation for repeat assessments * The presence of significant coronary lesions, other than the index lesion of the infarction related artery * A history of significant ventricular arrhythmia not related to index STEMI * A history of cerebro-vascular accident or transient ischemic attack within 6 months of enrollment * Inability to undergo apheresis procedure(i.e.: poor venous access, laboratory abnormalities * A history of uncorrected significant valvular heart disease * A history of left ventricular dysfunction prior to index STEMI * A history of human immunodeficiency virus (HIV)or hepatitis B or C infection * A history of malignancy within 5 years (Except for low-grade and fully resolved non-melanoma skin cancer) * A history of allergy to gentamycin or amphotericin * A history of non-compliance * Active inflammatory autoimmune disease requiring chronic immunosuppressive therapy * Creatinine clearance \<60 by Cockcroft-Gault Calculator * Confirmed pregnant or lactating * Is enrolled in a current investigational drug or device trial * Participant has received cell or gene therapy in past * The presence of any significant co-morbidities that, in the investigator's opinion, would preclude the participant from taking part in the trial * Inability to provide informed consent and comply with the follow-up visit schedule