The Efficacy of TCD Following by TP Maintenance Therapy in Newly Diagnosed WM

Inclusion Criteria: 1. Aged \>=18 years 2. diagnosed with WM 3. Untreated or mild treated without standard regimens,especially untreated with rituximab and/or bortezomib 4. symptom patients 5. with life-expectancy more than 3 months. Exclusion Criteria: 1. diagnosed with other malignancies outside B-NHL within one year(including active centre neural system lymphoma) 2. Transformed lymphoma 3. liver or renal function lesion unrelated to lymphoma 4. serious complications such as uncontrolled diabetes,gastric ulcer or other serious angiocardiopathy determined by the physician 5. HIV positive or active HBV infection or other uncontrolled systematic infection 6. clinical central nervous dysfunction 7. serious surgery within 30 days 8. pregnancy or baby nursing period or un-contracepted child-bearing period woman; 9. allergy to the trail drugs.