The purpose of this study is to evaluate the effects of a common over-the-counter medication, omeprazole, on the normal gut bacteria and inflammation in the body in healthy older adults.
This study aims to enroll 25 healthy subjects from San Antonio, Texas and the surrounding area. Study participants will be asked to provide a blood and stool sample at baseline, complete a 14-day course of omeprazole (Prilosec®), and then complete a follow-up blood and stool sample.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
BASIC_SCIENCE
Masking
NONE
Enrollment
25
20mg orally once daily
First Outpatient Research Unit, Medical Arts and Research Center
San Antonio, Texas, United States
Change in fecal microbiota diversity following omeprazole use
Bacterial taxa will be classified according to operational taxonomic units (OTUs). The change in the diversity of bacteria taxa will be compared between pre- and post-samples using the Bray-Curtis dissimilarity measure.
Time frame: 14 days
Change in interleukin inflammatory markers following omeprazole use
Interleukin 2, interleukin-6, and interleukin-10 will be measured from the blood at baseline and following omeprazole use and each reported in pg/mL.
Time frame: 14 days
Change in tumor necrosis factor-alpha following omeprazole use
Tumor necrosis factor-alpha will be measured from the blood at baseline and following omeprazole use and reported in pg/mL.
Time frame: 14 days
Change in insulin-like growth factor-1 due following omeprazole use
Insulin-like growth factor-1 will be measured from the blood at baseline and following omeprazole use and reported in ng/mL.
Time frame: 14 days
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