Treatment With Quetiapine for Youth With Substance Use Disorders and Severe Mood Dysregulation

Inclusion Criteria: * Male or female age 15 to 24 * Meet DSM-5 criteria for a substance use disorder * Substance use ≥ 14 days of past 28 days (i.e. use ≥ 50% of days in the past 28 days) * If subject in restricted setting/care (e.g. inpatient detox unit or residential treatment) for ≤ 2 weeks, then use ≥ 50% of days while outside of restricted setting (e.g. 7 days of substance use out of 14 days in unrestricted setting) * Subjects need to have been in an unrestricted setting for at least 2 weeks prior to screening * Meets DSM-5 criteria for bipolar disorder or disruptive mood dysregulation disorder or DSM IV criteria for mood disorder not otherwise specified * Symptoms of SMD: Youth Self Report (YSR) or Adult Self Report (ASR) AAA ≥180 * Stable to be treated in outpatient level of care Exclusion Criteria: * Current methamphetamine use disorder * Current unstable opioid use disorder (i.e. \< 3 months on medication assisted treatment for an opioid use disorder) * Pregnant or breastfeeding * Placement in a restricted setting (e.g. detox or residential treatment) for ≥ 2 weeks out of past 28 days prior to screening visit, or placement in a restricted setting at anytime during study participation * Unwilling or unable to use effective birth control * Unwilling or unable to sign release of information for the treatment program providing behavioral treatment * For participants \>17 years-unable or unwilling to identify emergency contact