The purpose of this study is to better characterize the fluctuations in multiple sclerosis symptoms and their relationship to medications, to length/extent of disease, and to a variety of physiologic measures.
Study Type
OBSERVATIONAL
Enrollment
2,200
Participants will be stratified into one of four cohorts based on their experience (or lack of experience) with the three major forms of multiple sclerosis.
Duke University Medical Center
Durham, North Carolina, United States
Change in perceived fatigue severity (self-report) as recorded by symptom diary
Time frame: Every 24 hours through study completion, an average of 6 months
Change in perceived cognitive impairment (self-report) as recorded by symptom diary
Severity of cognitive impairment experienced from multiple sclerosis
Time frame: Every 24 hours through study completion, an average of 6 months
Change in perceived depression or anxiety severity (self-report) as recorded by symptom diary
Severity of any mood disorders experienced from multiple sclerosis
Time frame: Every 24 hours through study completion, an average of 6 months
Change in perceived walking instability (self-report) as recorded by symptom diary
Time frame: Every 24 hours through study completion, an average of 6 months
Change in perceived vision difficulties (self-report) as recorded by symptom diary
Time frame: Every 24 hours through study completion, an average of 6 months
Change in perceived Bowel/Bladder dysfunction (self-report) as recorded by symptom diary
Severity of bowel/bladder dysfunction experienced from multiple sclerosis
Time frame: Every 24 hours through study completion, an average of 6 months
Change in perceived sensory disturbance (self-report) as recorded by symptom diary
Time frame: Every 24 hours through study completion, an average of 6 months
Change in perceived vertigo severity (self-report) as recorded by symptom diary
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Time frame: Every 24 hours through study completion, an average of 6 months
Change in perceived dysarthria severity (self-report) as recorded by symptom diary
Time frame: Every 24 hours through study completion, an average of 6 months
Change in pain (self-report) as recorded by symptom diary
Time frame: Every 24 hours through study completion, an average of 6 months
Change in sleep quality as recorded by app-linked wearable device
Time frame: Every 24 hours through study completion, an average of 6 months
Change in medication adherence (self-report) as recorded by medication diary
Time frame: Every 24 hours through study completion, an average of 6 months
Change in self-efficacy (self-report) as determined by the Multiple Sclerosis self-efficacy scale (survey instrument)
Time frame: every three months, through study completion (an average of 6 months)
Change in Multiple Sclerosis Quality of Life Inventory
The Multiple Sclerosis Quality of Life Inventory surveys are prompted based on the app user's responses on the daily surveys.
Time frame: prompted based on the app user's responses on the daily surveys, up to 6 months