Study to Assess the Safety, Tolerability, PK, ECG Effects, Food Effect, and Drug-drug Interaction (DDI) of Hormonal Contraceptives of PTI-428 in Healthy Female Volunteers

Inclusion Criteria: * Adult females age 18 - 55 years old, inclusive, at the time of informed consent. * For the DDI Oral Contraceptive Cohort, women of child bearing potential with intact ovarian function by medical history and history of regular menstrual. cycles. * Body mass index (BMI) ≥18 \< 30 kg/m2. * Subject must be non-smoker and non-tobacco user for a minimum of 30 days prior to screening and for the duration of the study. * Subject understands the full nature and purpose of the study, including possible risks and side effects, and is willing and able to comply with all compulsory study procedures and provides informed consent/permission prior to any study procedures being performed. Exclusion Criteria: * History or current evidence of any clinically significant cardiac, endocrinologic, hematologic, hepatobiliary, immunologic, metabolic, urologic, pulmonary, neurologic, dermatologic, psychiatric, renal, or other major disease, as determined by the Investigator. * Abnormal liver function as defined by: * Aspartate aminotransferase (AST), alanine aminotransferase (ALT) or bilirubin \> 1.5 x upper limit of the normal range. * Abnormal renal function at screening defined as: * Creatinine clearance \< 80mL/min using the Cockroft-Gault equation. * No clinically significant screening results that would exclude subject from the study (e.g., medical histories, physical examination, ECGs, vital signs,and laboratory profiles) as deemed by the investigator. * Platelet count \< 150,000 cell/mm3 * Participation in another clinical trial or treatment with an investigational agent within 30 days or 5 half-lives, whichever is longer, prior to Study Day 1. * History of cancer within the past five years (excluding non-melanoma skin cancer). * History of alcohol or drug abuse or dependence within 12 months of screening as determined by the Investigator. * Positive urine screen for prohibited drugs (cocaine, cannabinoids, nicotine \[urine cotinine is the detection mechanism for nicotine\], opiates, barbiturates, amphetamines, and benzodiazepines) or positive alcohol test at screening. * Positive blood screen for human immunodeficiency virus (HIV), hepatitis B surface antigen (HBsAg), or hepatitis C virus antibody (HCVAb). * Clinically significant infection within 3 months of screening as determined by the Investigator. * Known or suspected hypersensitivity or idiosyncratic reaction to study medication or any components thereof. * Has donated blood within 3 months of screening or plans to donate blood within 3 months of study completion. * Pregnant or nursing women. * Any conditions that, in the opinion of the Investigator, would make the subject unsuitable for enrollment or could interfere with the subject's participation in or completion of the study. * Females of child-bearing potential, unless they are willing to use highly effective methods of contraception during participation in the clinical study and for 30 days after termination from study. * Use of prohibited medications within 14 days prior to dosing of study drug.