The study aims to characterize the cerebral activation modifications related to nasal oxytocin administration during vizualisation of distress images in population of healthy people with different attachement styles.
Healthy adult male will be recruited. Their attachement style will be assessed through the Attachement scale interview (ASI). They will have 2 fMRI sessions, during which emotional images will be presented. One session will be preceded by a nasal administration of oxytocin and the other session will be preceded by a placebo nasal administration. The order of both administrations will be randomized.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
QUADRUPLE
Enrollment
100
nasal administration of oxytocin or palcebo 45 min befor fMRI session
FMRI during emotional image visualization
this scale is used to determine the attachement style of each participant
CHU Besancon
Besançon, Doubs, France
BOLD signal intensity
BOLD signal will be assessed in the brain regions associated with attachement: amygdala, medial prefrontal cortex and dorsolateral prefrontal cortex. Both conditions (placebo vs axytocin) will be compared in the four groups. BOLD signal will be assessed during the visualization of emotional pictures that ellicit distress, comfort or complicity or neural emotion.
Time frame: 45 min after intranasal administration of oxytocin or placebo
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self adminstrated questionnaires which asses the level of anxiety (Spielberger State-trait anxiety interview-STAI), depression (Beck depression inventory-BDI) and alexithymia (Toronta Alexuthymia scale-TAS 20)