Respiratory Viral Infections (RVI) are particularly frequent in young children. Old data mention the deleterious role of some viruses such as the Respiratory Syncytial Virus in young children with cystic fibrosis (CF). However, recent epidemiological data on RVI in CF children are rare and the impact of most frequent viruses such as human rhinoviruses is usually not correctly evaluated. The aim of this study is to assess the frequency of lower and upper RVI during a 1 year follow-up in CF infants and to evaluate the impact of RVI at a clinical, microbiological and therapeutic level. Our hypothesis is that frequent and/or clinically severe RVIs have the worst impact in the short term and without any particular link with a specific virus as previously described.
Study Type
INTERVENTIONAL
Allocation
NA
Masking
NONE
Enrollment
25
1 year follow-up in CF infants with clinical, microbiological and therapeutic assessments
Cystic Fibrosis Pediatric Reference Centrer, Hospices Civils de Lyon
Bron, France
Number of Respiratory Viral Infection
Time frame: up to 12 months
Identification of respiratory viruses in throat-swabs
A panel of 10 viruses will be tested using polymerase chain reaction (PCR) and RT-PCR technology.
Time frame: up to 12 months
Number of antibiotics treatments (oral or IV)
Time frame: up to 12 months
Number of bronchodilator administrations
Time frame: up to 12 months
Number of corticosteroids administrations
Time frame: up to 12 months
Number of hospitalization or hospital admission due to upper or lower RVI
Time frame: up to 12 months
Identification of bacterial flora in throat-swabs
Time frame: up to 12 months
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