This is a randomized pilot study to characterize engraftment of a donor's microflora onto patients with Irritable Bowel Syndrome with diarrhea following fecal microbiota transplantation.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Enrollment
80
fecal microbiota transplantation
placebo fecal microbiota transplantation
FMT with antibiotic pre-treatment (v1)
Beth Israel Deaconess Medical Center
Boston, Massachusetts, United States
stable engraftment of donor microbiota
Stable engraftment will be defined with the Jensen-Shannon Divergence (JSD) between the bacteria community measured in the donor and recipient. Engraftment scores will be defined by the ratio between the JSD in comparison between the recipient and donor and the recipient and other healthy donors not providing material for their FMT.
Time frame: 10 weeks
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FMT with antibiotic pre-treatment (v2)