The purpose of this study is to examine whether playing recordings of a mother's voice to her infant while in the hospital nursery is an effective treatment for promoting healthy brain and language development in infants born preterm.
Children born preterm are at-risk for developmental language delays. Language problems in preterm children are thought to be related to neurobiological factors, including injuries to white matter structures of the brain and environmental factors, including decreased exposure to maternal speech in the hospital nursery. There is evidence to suggest that maternal speech input may be important for promoting healthy brain and language development. Participants will be randomly assigned to one of two study groups. Each infant has a 50% chance of being assigned to the group that will listen to a recording of his/her mother's voice and a 50% chance of being assigned to the group that will not be played a voice recording. Mother's of participating infants will have her voice recorded as she reads a common children's storybook. Recordings will be played to infants each day until s/he is discharged from the hospital. Participation in this study requires that all infants receive up to an additional 10 minutes of brain scans as part of his/her routine clinical magnetic resonance imaging (MRI).
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
TRIPLE
Enrollment
46
Recording of a mother's voice reading a children's storybook.
Standard of Care
Stanford University - Lucile Packard Children's Hospital
Palo Alto, California, United States
White matter mean diffusivity
Mean diffusivity measures the average rate of water diffusion within a given MRI voxel.
Time frame: 36-37 weeks post-menstrual age or at time of hospital discharge, whichever comes first
Length of hospital stay
Days in hospital since birth and until discharge
Time frame: Days in hospital since birth and until discharge, average range is 37-40 weeks postmenstrual age (PMA)
Average daily weight gain
Time frame: measured daily and beginning at start of treatment and until end of treatment, approximately 37-40 weeks PMA
Time (days) to full oral feed
days until 100 % of nutrition administered orally
Time frame: measured daily and beginning at start of treatment and until end of treatment, approximately 37-40 weeks PMA
Number of significant apnea and bradycardia events requiring stimulation
Time frame: measured daily and beginning at start of treatment and until end of treatment, approximately 37-40 weeks PMA
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