Effects of Replacement Therapy With Sexual Steroid Hormones on the Insulin Sensitivity of Hypogonadal Man

University Hospital, Caen6 enrolled

Overview

Sexual steroids administered to supra-physiological doses are likely to change the carbohydrate and lipid metabolism. Investigators propose to study in 12 hypogonadal men hypogonadotropic or hypergonadotropic treated with aromatase inhibitor, the respective effects of estradiol, testosterone or both steroids administered in a cross-over Latin squares plan on insulin sensitivity measured by the reference method of the hyperinsulinemic euglycemic clamp.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

Hypogonadism

Interventions

Estradiol (Insulin sensitivity)BIOLOGICAL

Testosterone (Insulin sensitivity)BIOLOGICAL

Eligibility

Sex: MALEMin age: 18 YearsMax age: 60 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Hypogonadism hypogonadotropic or hypergonadotropic * Man aged 18-60 years * BMI between 18 and 27. Exclusion Criteria: * Other ante-pituitary deficiency * Chronic treatment modifying carbohydrate metabolism (thiazides, beta 2 mimetics, steroids ...) * Diabetes * Obesity diffuse or android * Hemochromatosis * osteoporosis * chronic diseases * neoplasia * High blood pressure

Locations (1)

Endocrinology Unit and Clinical Research Center Basse Normandie, University Hospital of Caen

Caen, France

Outcomes

Primary Outcomes

GIR (glucose infusion rate) during euglycemic hyperinsulinemic clamp

Time frame: change between baseline and after 4 weeks of treatments

Data from ClinicalTrials.gov

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