CDH - Optimisation of Neonatal Ventilation

King's College London18 enrolled

Overview

To determine the appropriate volume (size) of ventilator breath during volume-targetted ventilation for infants born with congenital diaphragmatic hernia.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

Congenital Diaphragmatic Hernia

Interventions

Measurement of PTPdiDEVICE

Insertion of pressure transducer catheter to measure gastic and oesophadgeal pressures for calculation of PTPdi

TTV at 4ml/kgDEVICE

Provision of targetted tidal volume of 4ml/kg

TTV at 5ml/kgDEVICE

Provision of targetted tidal volume of 5ml/kg

Eligibility

Sex: ALLMax age: 6 Months

Medical Language ↔ Plain English

Inclusion Criteria: * Congenital diaphragmatic hernia - post-operative Mechanically ventilated Born at \>34/40 Exclusion Criteria: * neuromuscular blockade contraindications to NG/OG tube insertion

Locations (1)

King's College Hospital

London, United Kingdom

RECRUITING

Outcomes

Primary Outcomes

Change in Pressure Time Product of the diaphragm (PTPdi) at different levels of targetted tidal volume

PTPdi will be measured at each level of tidal volume. The outcome measure is the change in PTPdi.

Time frame: 3 hours

Central Contacts

Katie Hunt, MA, MBBS

CONTACT

00442032999000 katie.a.hunt@kcl.ac.uk

Data from ClinicalTrials.gov

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