Both laparoscopic partial nephrectomy (LPN) and robotic partial nephrectomy (RPN) can be performed through transperitoneal (TP) or retroperitoneal (RP) approach. RP approach is less utilized than TP approach because of technical difficulties when using rigid laparoscopic instruments in the small space of retroperitoneum cavity. However, with advanced surgical skills and thoughtful patient selection, RP approach may be associated with shorter operative time (OT), less estimated blood loss (EBL), shorter length of hospital stay (LOS) compared with TP approach. Therefore, the investigators performed randomized control trial to compare the outcomes of the two approaches (TP-LPN or RPN vs RP-LPN or RPN).
Partial nephrectomy is the standard treatment for small renal masses. The evolution of minimally invasive partial nephrectomy led to widespread utilization of laparoscopic (LPN) and robotic partial nephrectomy (RPN). Both LPN and RPN can be performed through transperitoneal (TP) or retroperitoneal (RP) approach. RP approach is less utilized than TP approach because of technical difficulties when using rigid laparoscopic instruments in the small space of retroperitoneum cavity. However, with advanced surgical skills and thoughtful patient selection, RP approach may be associated with shorter OT, less EBL, shorter LOS compared with TP approach. Therefore, the investigators performed randomized control trial to compare the outcomes of the two approaches (TP-LPN or RPN vs RP-LPN or RPN). The purpose of this study To compare the treatment outcomes of the transperitoneal and retroperitoneal approach during LPN or RPN in treatment of small renal masses. Inclusion criteria During the study period, a small renal mass (less than 4cm, T1a stage) patients are going to underwent LPN or RPN. Exclusion criteria 1. Patients who underwent radical nephrectomy 2. Patients with bilateral renal masses 3. Patients with a solitary kidney 4. Patients reject a written informed consent 5. Pregnancy The number of target subjects More than 106 patients who meet the inclusion criteria
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
TRIPLE
Enrollment
106
Laparoscopic or robotic partial nephrectomy of a small renal masses (T1a) through transperitoneal or retroperitoneal approach
Samsung Medical Center
Seoul, Seoul, South Korea
RECRUITINGOperative time
Operative time of partial nephrectomy
Time frame: Intraoperative
Warm ischemic time (minutes)
Vessel clamping time during partial nephrectomy
Time frame: Intraoperative
Number of participants with treatment-related adverse events as assessed by Clavien-Dindo classification
Time frame: from date of surgery, to 1 year postoperatively
Change of differential glomerular filtration rate (dGFR) measured by renal scan
Time frame: Preoperative dGFR and postoperative 1 year
Overall disease-free survival time (month)
Disease free means no local recurrence, no metastasis.
Time frame: from date of surgery, to 1 year postoperatively
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.