Effects of Probiotics on Cognition and Health

University of Illinois at Urbana-Champaign24 enrolled

Overview

This research intervention aims to examine the effects of a fermented dairy beverage on changes in behavioral and biological measures of cognition and stress among adults.

Evidence-based dietary strategies provide behavioral means benefiting physical and cognitive function. Pertinent to the proposed work, dietary intake has been recently shown to have the potential to directly influence the gut microbiota composition as well as brain function. Specifically, the consumption of probiotics or foods containing healthful microbial cultures (e.g., fermented milk, yogurts, etc.) are increasingly being recognized as modulators of metabolism, cognition, and stress. These foods are readily available in the marketplace, however, their implications for physical and cognitive function are not clear. Accordingly, the proposed study aims to investigate effects of probiotic beverage consumption on changes in behavioral and biological measures of cognition and stress among adults.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

DOUBLE

Enrollment

Conditions

Physiological Stress Cognition - Other

Interventions

Lactose Free 1% MilkOTHER

isocaloric study treatment containing lactose free 1% milk consumed once daily over 4-5 weeks as a control.

Probiotic TreatmentOTHER

Probiotic treatment, consumed once daily, over 4-5 weeks.

Eligibility

Sex: ALLMin age: 25 YearsMax age: 45 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Males and females * Between the ages of 25-45 years at the time of consent * BMI ≥18.5 kg/m2 * Normal or corrected-to-normal vision based on the minimal 20/20 standard in order to complete the cognitive task. * Ability to drop-off fecal sample within 15 minutes of defecation Exclusion Criteria: * Current pregnancy or lactation * Tobacco use * Dairy allergy or intolerance * Prior diagnosis of metabolic and gastrointestinal disease (cardiovascular disease and type 1 or type 2 diabetes, chronic constipation, diarrhea, Crohn's disease, celiac disease, ulcerative colitis, irritable bowel syndrome, diverticulosis, stomach or duodenal ulcers, hepatitis, HIV, cancer, etc.) * Prior diagnosis of cognitive or physical disability, including ADHD, severe asthma, epilepsy, chronic kidney disease * Use of any anti-psychotic, anti-depressant, anti-anxiety, or ADD/ADHD medications * Use of medications that alter normal bowel function and metabolism (e.g., recent antibiotic use, laxatives, enemas, anti-diarrheal agents, narcotics, antacids, antispasmodics, diuretics, anticonvulsants). * Prior malabsorptive bariatric surgery (i.e. gastric bypass, sleeve gastrectomy) or restrictive bariatric surgery (i.e. adjustable gastric band) within the past 2 years.

Locations (1)

University of Illinois

Urbana, Illinois, United States

Outcomes

Primary Outcomes

Changes in cortisol as a biomarker of stress

The effects of probiotic consumption on biomarkers of stress

Time frame: 4-5 weeks

Secondary Outcomes

Changes in fecal microbiota populations

The effects of probiotic consumption on fecal microbiota

Time frame: 4-5 weeks

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.