Body composition analysis and especially body fat distribution in regions of interest (android and in particular intra-abdominal region) provides some information on the risk of cardiovascular disease. There is little data available on the body composition analysis in psoriasis and psoriatic arthritis (diseases with higher risk of cardiovascular disease), in particular data on fat distribution in regions of interest regarding the risk of cardiovascular disease. Adipokines, secreted by the adipose tissue, have pro or anti-inflammatory and metabolic properties that are interesting to explore in pathologies with a higher risk of cardiovascular disease like psoriasis or psoriatic arthritis. Adipokines have been investigated in psoriasis but fat tissue and in particular its distribution (android/visceral or intra-abdominal) has not been studied in parallel. Moreover, relation between adipokines and psoriasis area or severity has been studied but the relation between adipokines and cardiovascular risk factors has not yet been investigated. The aim of this study is to investigate relations between the body fat distribution, adipokines rates and the risk of cardiovascular disease of these patients.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
BASIC_SCIENCE
Masking
NONE
Enrollment
199
Chru Besancon
Besançon, France
Android fat distribution measured by bone densitometry (DEXA) (LUNAR GE iDXA device)
Time frame: day 1
Body fat
Time frame: day 1
body masses
Time frame: day 1
Intra-abdominal body fat mass (measured by CoreScan)
Time frame: day 1
Gynoid distribution of body fat
Time frame: day 1
SCORE (Systematic COronary Risk Evaluation).
Time frame: day 1
levels of adipokines
Time frame: day 1
Homeostasis model assessment of insulin resistance
Time frame: day 1
Bone mineral density of rachis, femoral neck, whole body
Time frame: day 1
levels of ghrelin
Time frame: day 1
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