NO is an ubiquitous molecule contributing to many physiological functions such as vasodilation, immune and oxidative stress responses. NO production can be supplemented either by providing substrate to the NO-synthase (L-Arginine and L-Citruline) or by providing nitrate which can lead to NO. In the present project the investigators evaluate the effect of various acute and chronic oral NO precursors supplementation on exercise performance and responses in healthy young and older subjects.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
TRIPLE
Enrollment
63
Subjects will be supplemented orally either acutely or chronically (4-8 weeks) with NO precursors.
Subjects will be supplemented orally either acutely or chronically (4-8 weeks) with NO precursors.
Subjects will be supplemented orally either acutely or chronically (4-8 weeks) with NO precursors.
Grenoble University Hospital
Grenoble, Auvergne-Rhône-Alpes, France
Neuromuscular evaluations
After the intake of the supplement. Measure the stretching force in the ankle (N)
Time frame: 3 half days
Evaluation of post-ischemic vascular reactivity
After the intake of the supplement. Concentration of hemoglobin (g/mL) in the quadriceps with the device : NIRS system Oxymon, ARTINIS.
Time frame: 3 half days
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Subjects will be supplemented orally either acutely or chronically (4-8 weeks) with a placebo.
After the intake of the supplement. Concentration of hemoglobin (g/mL) in the quadriceps with the device : NIRS system Oxymon, ARTINIS.
After the intake of the supplement. Measure the stretching force in the ankle (N)