Driving Pressure and Postoperative Pulmonary Complications

Samsung Medical Center312 enrolled

Overview

This study aims to prove that driving pressure limited ventilation is superior in preventing postoperative pulmonary complications to existing protective ventilation.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

TRIPLE

Enrollment

312

Conditions

One-Lung Ventilation Postoperative Respiratory Complications Driving Pressure

Interventions

Driving Pressure Limited VentilationOTHER

Positive end expiratory pressure is adjusted to minimize driving pressure, plateau pressure minus end expiratory pressure from 2 to 10 cmH2O during one-lung ventilation

Eligibility

Sex: ALLMin age: 19 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Adults greater than or equal to 19 years * Patient who undergoes one-lung ventilation for thoracic surgery Exclusion Criteria: * The American Society of Anesthesiologists (ASA) Physical Status classification greater than or equal to 4 * Patient who is contraindicated with application of positive end expiratory pressure * Patient who rejects being enrolled in the study

Locations (1)

Samsung medical center

Seoul, South Korea

Outcomes

Primary Outcomes

The incidence of postoperative pulmonary complications

Patient is regarded to have postoperative pulmonary complication when 4 or more positive variables exists according to Melbourne Group Scale.

Time frame: within the first 3 days after surgery

Secondary Outcomes

Partial pressure of oxygen in arterial blood

Time frame: during surgery

The ratio of partial pressure arterial oxygen and fraction of inspired oxygen

The ratio will be obtained from the first arterial blood gas analysis on the first postoperative day.

Time frame: on the first postoperative day

Data from ClinicalTrials.gov

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