Phospholipid and Sphingolipid Composition of High-density Lipoproteins (HDL) in Obese Non-diabetic Patients With Metabolic Syndrome

Inclusion Criteria: * aged \> 18 years * fasting glycaemia \< 1.10 g/l * waist circumference \> 102 cm for men and 88 cm for women (criteria NCEP/ATP III) * 2 criteria among the following 3 (NCEP/ATP III criteria for metabolic syndrome): * triglyceridaemia ≥ 1.50 g/l * HDL cholesterol \< 0.40 g/l for men and 0.50 g/l for women * arterial blood pressure ≥ 130/85 mmHg or treatment for arterial hypertension * patients who have provided written consent INCLUSION CRITERIA FOR HEALTHY SUBJECTS * age \> 18 years * fasting glycaemia \< 1.10 g/l * waist circumference \< 102 cm for men and 88 cm for women * triglyceridaemia \< 1.50 g/l * HDL cholesterol ≥ 0.40 g/l for men and 0.50 g/l for women * Healthy subjects who have provided written consent Exclusion Criteria: * Persons without national health insurance cover * Diabetes * Diseases that interfere with lipoprotein metabolism (dysthyroidism not controlled with the treatment, kidney or liver disease) * Treatments that interfere with lipoprotein metabolism (lipid-lowering agents, oestrogens, corticoids, retinoids, antiretroviral agents) * Pregnancy/breast feeding