Interest of ß 1-3 D Glucan Assays in Screening for the Onset of Invasive Aspergillosis in Neutropenic Patients With Acute Leukaemia.

Centre Hospitalier Universitaire Dijon476 enrolled

Overview

In the context of screening for infectious fungal diseases in patients with malignant haemopathy, and particularly patients with acute leukaemia, the investigator aims to evaluate the performance of an already commercialized but little used serum screening test (Fungitell® test) and to determine its place in the management strategy for invasive aspergillosis.

Study Type

INTERVENTIONAL

Allocation

NON_RANDOMIZED

Masking

NONE

Enrollment

476

Conditions

Invasive Fungal Infections

Interventions

blood samplesBIOLOGICAL

Eligibility

Sex: FEMALEMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Patients who have been informed about the study * Patients over 18 years * patients with acute myeloblastic leukaemia (AML) or lymphoblastic leukaemia (ALL) who have undergone cytotoxic chemotherapy with curative intent Exclusion Criteria: * Adults under guardianship * Patients without national health insurance cover * Pregnant or breast-feeding women * allografts and autografts of Haematopoietic Stem Cells (HSC)

Locations (1)

CHU Dijon Bourgogne

Dijon, France

Outcomes

Primary Outcomes

Comparison of the results of the 1-3 ß D glucan serum assay obtained with the Fungitell® test and the test currently used (in terms of specificity, sensitivity, negative predictive value and positive predictive value

Time frame: 8 to 10 assays over 4 to 5 weeks of hospitalization

Data from ClinicalTrials.gov

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