Single and Multiple Dose Safety, Tolerability, PK and Food Effect Study of PAT-1251 in Healthy Adult Subjects

Inclusion Criteria: * body mass index (BMI) between 18.0 and 30.0 kg/m2, inclusive * body weight of 50 to 100 kg, inclusive * subjects must be in good health Exclusion Criteria: * male subjects who do not agree, or whose partners of childbearing potential do not agree, to use appropriate contraception * female subjects of childbearing potential who do not agree to use 2 acceptable methods of contraception * history of, any clinically significant major disorder * clinically significant allergic condition * significant history of alcoholism or drug/chemical abuse * use of any tobacco or nicotine-containing products * clinically significant abnormality in heart rate, blood pressure, temperature, respiration rate, electrocardiogram or clinical laboratory findings * positive urine drugs of abuse screen or alcohol breath test