Effect of Food on the Bioavailability of 15 mg Estetrol/3 mg Drospirenone Tablets in Healthy Female Volunteers

Inclusion Criteria: * Overtly healthy females. * Between the ages of 18 and 45 years, inclusive. * Non-smokers who have not used tobacco or nicotine in any form during the 3 months prior to the screening visit. * Between the body mass index (BMI) of 18 and 30 kg/m2, inclusive, and body weight 45kg. * Negative serum pregnancy test results at screening and negative urine pregnancy test results before dosing. * Willing to use double-barrier methods of non-hormonal contraception during the entire study period. Exclusion Criteria: Potential study subjects were not entered into and/or may have been discontinued from the study if any of the following applied: * Use of * progestogen-only contraceptive methods \[e.g., minipill, implant or, intrauterine system (IUS)\] during the last 3 months prior to the first dose or, * depot progestogen preparations or an injectable hormonal method of contraception (e.g., Depo-Provera) during the last 6 months prior to the first dose. * Use (within 28 days prior to first dose) of other hormonal contraceptive method. * Use of * any prescription drugs (except thyroid hormone supplements) or herbal supplements acting on CYP3A4 functions (e.g., St. John's Wort), within 28 days prior to the first dose until study completion, * any over-the-counter (OTC) medication (including paracetamol) or dietary supplements (vitamins included) within 14 days prior to the first study dose until study completion.