This study aims at investigating the acute influence of artificially sweetened beverages consumption (as compared with sugar-sweetened beverages and water consumption) on brain responses to the viewing of food images, on physiological responses (gut-derived hormones and lipid metabolites) and on the food intake behavior.
This study is made on a randomized controlled crossover design including three conditions (water, sugar, artificial sweeteners). Measurements will be performed in fasting and fed conditions. The test-meal will comprise either an artificially or sugar-sweetened beverage or water (control). The spatio-temporal brain dynamics to the viewing of food pictures will be assessed by means of electroencephalography (EEG) recordings and electrical neuroimaging analyses. Venous blood and urine will be collected. Blood pressure, cardiac frequency and bio-impedance measurements will be performed. Food intake behavior will be assessed by means of questionnaires and a free-choice buffet. Each tested condition (water, sugar, artificial sweeteners) will be preceded by a run-in period during which the participants' diet will be controlled (2-day isoenergetic diet).
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
TRIPLE
Enrollment
18
participants will ingest a test meal containing 55% carbohydrate, 30% fat and 15% protein with artificially sweetened drinks
participants will ingest a test meal containing 55% carbohydrate, 30% fat and 15% protein with sugary drinks drinks
participants will ingest a test meal containing 55% carbohydrate, 30% fat and 15% protein with waters
Department of Physiology
Lausanne, Canton of Vaud, Switzerland
Spatio-temporal brain dynamics
Spatio-temporal brain dynamics to the viewing of food will be assessed by means of electroencephalography recordings.
Time frame: differences observed between 60 min before and 60 min after ingestion of a test meal
Changes in concentration of blood insulin
Blood substrate concentration will be measured in fasting conditions and after ingestion of a test meal
Time frame: -120 min before ingestion of a test meal, and 30, 60, 90, 150, and 210 min after ingestion of a test meal
Changes in concentration of blood triglyceride
Blood substrate concentration will be measured in fasting conditions and after ingestion of a test meal
Time frame: -120 min before ingestion of a test meal, and 30, 60, 90, 150, and 210 min after ingestion of a test meal
Changes in concentration of blood Fibroblast Growth Factor (FGF)-21
Blood substrate concentration will be measured in fasting conditions and after ingestion of a test meal
Time frame: -120 min before ingestion of a test meal, and 30, 60, 90, 150, and 210 min after ingestion of a test meal
spontaneous food intake
Food intake behavior will be assessed by monitoring spontaneous food intake when offered a free-choice buffet.
Time frame: 240 min after ingestion of a test meal
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.