Neural Progenitor Cell and Paracrine Factors to Treat Hypoxic Ischemic Encephalopathy

Inclusion Criteria: 1. gestational age ≥ 34weeks, body weight ≥ 2kg. 2. 1 minute apgar score ≤3, and 5 minutes apgar score ≤5, OR umbilical arterial blood gas potential of hydrogen\<7.0, OR 30 minutes base excess≤-12 mmol/L, OR need for ventilation 5 minutes after birth. 3. All infants must have signs of encephalopathy (such as convulsion, coma, dystonia, abnormal primitive reflex and irregular respiration) within 6 hours of age or continued abnormal EEG for more than 24h. Exclusion Criteria: 1. Does not meet the inclusion criteria 2. Suffer from other serious organic disease or congenital, hereditary metabolic diseases 3. Intracranial active infection, or neuromuscular damage outside central nervous system 4. potential of hydrogen / electrolyte disorders without improvement or stability 5. Coagulation disorders associated with bleeding tendency 6. Immune function is not perfect 7. Patients or his guardian refuse consent. 8. Patients or his guardian don't accept the follow-up schedule.