Health Economic Analysis of Islet Cell Transplantation for the Stabilization of the Severe Forms of Type 1 Diabetes

Inclusion Criteria : * Suffering from diabetes since more than 5 years * Patient with brittle type 1 diabetes despite an optimized insulin treatment and educational training will be included. A patient will be considered as experiencing a brittle type 1 diabetes if at least two criteria are present among: persistence of severe hypoglycemia, occurrence of ketoacidosis events without obvious etiology, diagnosis of unaware hypoglycemic episodes \< 3 mmol/l based on CGM or self-monitoring blood glucose data, a mean blood glucose standard deviation\>50%, MAGE index (Mean amplitude of glucose excursions)\>60 mg/dl, LBGI index (low blood glucose index)\>5, Clarke score≥4 or HYPOSCORE\>800. * Insulin needs \< 0,85 U/kg/day * HbA1c \< 12% ; * No residual insulin secretion (plasmatic basal and stimulated C-peptide \< 0.3 ng/ml) * Social Security membership or benefit from Social Security * Patients who signed the consent form Exclusion Criteria : Exclusion criteria related to islet infusion: * Hemostatic disorders, pre-existing liver disease (PAL, Gamma-GT, ASAT-ALAT \>2N) or vesicular lithiasis. Exclusion criteria related to diabetic complications: * Evolutive proliferative retinopathy, evolutive nephropathy (Glomerular filtration rate \<30 ml/min/1.73m2 and/or proteinuria \>0.5g/day), evolutive cardiopathy or obliterative arteriopathy with trophic cutaneous lesions. Exclusion criteria related to immunosuppressant use: * Hemoglobin \< 110mg/dL in women and \< 120 mg/dL in men, leuconeutropenia, thrombopenia, systemic infection including chronic hepatitis B, C and VIH, neoplasia disease and hypertension\>160/100 mmHg. * Corticoid treatment (except for patient that benefited from a kidney graft with maintenance steroid therapy) * Presence of anti-HLA antibody directed against the donor * Positive B or T cells crossmatch