Retrospective analysis of ferritin, outcome and HLH-criteria in critically ill patients.
The study is a retrospective register study of critically ill patients from Charité - Universitätsmedizin Berlin during 2000 and 2016 that had at least one measurement of plasma ferritin. Outcome, underlying diagnoses and HLH-2004 criteria (Henter JI et al. 2007) will be analyzed and the HScore of these patients will be calculated (Fardet L et al. 2014). All recorded data of the specific admission term in ICU will be used for the analysis. No follow-up of the patients after discharge will be performed in this study. The study does not involve any randomization or any drug testing. Update 2019: We expanded our database for the years until 2018 and also for the surgical and medical ICUs of the Charité - Universitätsmedizin Berlin (from 256 to 2623 patients). Update 2022: A systematic literature search will be performed to find suitable validation cohorts for multicenter validation of optimized HLH diagnostic criteria, which are calculated based on our data (new secondary endpoint).
Study Type
OBSERVATIONAL
Enrollment
2,623
Mortality
A retrospective analysis of patients with available charts to determine the outcome whether patients survived the ICU or died.
Time frame: Participants will be followed up for the duration of hospital stay, an expected average of two months
Probability of having undiagnosed Hemophagocytic lymphohistiocytosis (HLH)
Retrospective analysis of available charts, underlying diagnoses, findings and blood values: HLH-2004 criteria (Henter JI et al. 2007) and HScore (Fardet L et al. 2014)
Time frame: The participants will be followed up for the duration of hospital stay, an expected average of two months
Diagnoses
Retrospective analysis of available charts and underlying diagnoses
Time frame: Participants will be followed up for the duration of hospital stay, an expected average of two months
Intensive care unit stay
Retrospective analysis of available charts and duration of ICU stay
Time frame: Participants will be followed up for the duration of intensive care unit stay, an expected average of one week
Improving HLH diagnostic criteria including multicenter validation
Sensitivity and specificity of HLH diagnostic criteria should be improved by calculating different cutoffs of HLH-2004 criteria. Combinations with highest sensitivity and specificity will be validated in published cohorts of HLH testing for sensitivity and specificity.
Time frame: Participants will be followed up for the duration of intensive care unit stay, an expected average of one week
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