Parkinson's disease (PD) is a common disease. Dementia will affect 80% of these patients during their evolution. In addition, treatments of motor signs have a potential impact on these disorders and conversely. The purpose of this study is to show focal abnormalities in brain metabolism in the precuneus and posterior cingulate region are predictive of the onset of dementia within 2 years.
Cognitive impairment and dementia have become major factors of disability induced by Parkinson's disease. The prediction of dementia in any given patient may be useful for prognosis but also for discussion of setting up heavy therapeutic techniques, especially surgical. Currently, known predictors are disease severity, age and existence of pre-cognitive disorders; other assumptions are discussed. Among these, morphological imaging techniques (MRI) and functional techniques (MRI, PET) are proposed. Use increasingly early of heavy, expensive and potentially ineffective surgical treatment in dementia makes it necessary to find independent, early and reliable markers of the onset of dementia in Parkinson's Disease.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
DIAGNOSTIC
Masking
NONE
Enrollment
138
Imaging tests and neuropsychological assessment are carried out within 60 days following patient enrollment. Neuropsychological assessment lasts 1:30 to 2:00 hours and is conducted by a psychologist in an interview during which patient will pass several tests on memory, language, attention or orientation in space. These tests do not require discontinuation of Parkinson's disease treatment.
Henri Mondor Hospital
Créteil, France
Onset of dementia authenticated by a neuropsychological assessment (MDS Task Force criteria)
Time frame: Year 2
Regional cerebral glucose consumption in the parietal lobes studied with fluorodeoxyglucose (FDG) Positron Emission Tomography (PET) and regional glucose consumption in the caudate nucleus and prefrontal areas studied with FDG PET
Time frame: Day 90
Determination of cerebral blood flow (CBF) by arterial spin labelling (ASL) perfusion 3Tesla (3T) Magnetic Resonance Imaging (MRI)
Time frame: Day 90
Identifying different striatal functional connectivity patterns by resting state functional MRI at 3T
Time frame: Day 90
Cerebral cortex trophicity by VBM technique (Voxel-based morphometry)
Time frame: Day 90
Number of hyperintensities in the FLAIR MR image
Time frame: Day 90
Concentration of iron in the mesencephalon measured with MRI
Time frame: Day 90
Degree of anosmia measured with the University of Pennsylvania Smell Identification Test (UPSIT)
Time frame: Day 90
Correlation between initial clinical, neuropsychological and biological parameters and risk of onset of dementia
Time frame: Day 0 and year 2
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.