Evaluation of the Free α-hemoglobin Pool in the Red Blood Cells : Prognostic Marker and Severity Index in Thalassemic Syndromes

Inclusion Criteria Patient * Age ≥ 18 years * Written informed consent * Affiliation to social security * Known Hb Phenotypes * Biological phenotype corresponding to a classical picture of thalassemia Healthy volunteers * Age ≥ 18 years * Written informed consent * Affiliation to social security Exclusion Criteria Patient * Transfusion for less than 3 months * Chronic active viral disease: hepatitis B, C, HIV * Ongoing infections or known inflammatory diseases * Hyper or Hypothyroidism known or subject treated by Levothyrox * Active pathology or tumor remission for less than 5 years * Oral corticosteroid * Hemoglobinopathy other than thalassemia for patients * Treatment by Hydroxyurea for more than 3 months * Treatment by stimulating agent erythropoiesis for longer than 3 months Healthy volunteers * Transfusion for less than 3 months * Chronic active viral disease: hepatitis B, C, HIV * Ongoing infections or known inflammatory diseases * Hyper or Hypothyroidism known or subject treated by Levothyrox * Active pathology or tumor remission for less than 5 years * Oral corticosteroid * Genetically related to person with hemoglobinopathy