This research trial studies the shotgun sequencing of blood samples in diagnosing febrile neutropenia in patients with acute myeloid leukemia. Studying samples of blood from patients with acute myeloid leukemia in the laboratory may help identify pathogens and accurately diagnose infections such as febrile neutropenia.
PRIMARY OBJECTIVES: I. To test the hypothesis that shotgun metagenomics is not inferior to standard of care diagnostics in the detection of pathogens in patients with febrile neutropenia. SECONDARY OBJECTIVES: I. To establish a microbiological diagnosis with known or unknown pathogens in patients in whom standard care failed to yield a pathogenic diagnosis. OUTLINE: Patients undergo collection of blood samples before and during the episode of febrile neutropenia for up to 6 weeks.
Study Type
OBSERVATIONAL
Enrollment
56
Undergo collection of blood
Correlative studies
Stanford University, School of Medicine
Palo Alto, California, United States
Detection of pathogens in patients with febrile neutropenia assessed by shotgun metagenomics
Will be compared to standard of care diagnostics in the detection of pathogens in patients with febrile neutropenia.
Time frame: Up to 6 weeks
Number and frequency of novel pathogens found
Time frame: Up to 6 weeks
Proportion of patients with any pathogen by the standard, where the shotgun did not indicate the presence of the pathogen
Time frame: Up to 6 weeks
Proportion of patients with false negative
Time frame: Up to 6 weeks
Proportion of patients with false positives
Time frame: Up to 6 weeks
Proportion of patients with mitochondrial DNA detected
Time frame: Up to 6 weeks
Microbiological diagnosis with known or unknown pathogens in patients in whom standard care failed to yield a pathogenic diagnosis assessed by shotgun metagenomics
Time frame: Up to 6 weeks
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