The aim of the trial is to study a radiating diagnosis agent used in post surgery when the biological assessment highlighted a residual disease. This is an inter-regional multicentric, prospective study evaluating the benefit of PET F-DOPA imaging in involved node detection compared to standard imaging assessment in patient with medullary thyroid cancer. The purpose of the study is to evaluate the impact and performance of a new PET / CT (computerized tomography ) tracer targeting dopamine receptor in patient with residual ganglionar biological disease after initial surgery of medullary thyroid cancer compared to standard imaging. Obtained data will be compared to the "gold standard" based on : * nodes cytology when they could be punctured * histology when a new surgery will be recommended * surveillance when the 2 first cases will be not applicable (imaging monitoring, evolution of thyrocalcitonin)
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
DIAGNOSTIC
Masking
NONE
Enrollment
24
Injection of 18F-DOPA and PET / CT-scan assessment
CHU Haut-Lévêque
Bordeaux, France
CHU Limoges
Limoges, France
CHU Timone
Marseille, France
ICM Montpellier
Montpellier, France
Institut Claudius Regaud
Toulouse, France
Relative rate of TRUE positive nodes with PET F-DOPA compared to standard imaging assessment.
Analysis will be performed by node.
Time frame: up to 3 years
Relative rate of TRUE positive nodes with PET F-DOPA compared to standard imaging assessment.
Analysis will be performed by patient.
Time frame: up to 3 years
Relative rate of FALSE positive nodes with PET F-DOPA compared to standard imaging assessment.
Analyses will be performed by patient and by node.
Time frame: up to 3 years
Relative rate of TRUE positive and FALSE metastasis with PET F-DOPA compared to standard imaging assessment.
Analyses will be performed by patient and by metastasis.
Time frame: up to 3 years
Modification rate of patient's care after PET F-DOPA exam.
Comparison of the modification of care (orientation to a surgery or a surveillance) decided after standard imaging assessment following result of TEP-FDOPA exam.
Time frame: up to 3 years
The concordance between the PET F-DOPA results of each centre and centralized review.
Concordance (centre / reviewer) of PET F-DOPA result interpretation will be evaluated.
Time frame: up to 3 years
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.