Acute pulmonary edema (APE) is a common condition in the emergency room, associated with considerable mortality. The use of intravenous morphine in the treatment of APE remains controversial and Benzodiazepines have been suggested as an alternative for morphine to relieving dyspnoea and anxiety in the patients with APE. The MIdazolan versus MOrphine in APE trial (MIMO) is a multicenter, prospective, open-label, randomized study designed to evaluate the efficacy and safety of morphine in patients with APE.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
111
Hospital Universitario Reina Sofía de Córdoba
Córdoba, Andalusia, Spain
Hospital Comarcal de la Axarquía
Málaga, Andalusia, Spain
Hospital Clínic i Provincial de Barcelona
Barcelona, Catalonia, Spain
Hospital Universitario de Canarias
San Cristóbal de La Laguna, Santa Cruz De Tenerife, Spain
In-hospital Mortality
In hospital mortality
Time frame: 28 days after of the hospitalization
Number of Participants That Required Invasive Mechanical Ventilation
Time frame: Up to 1 week
Length of Hospital Stay
Length of hospital stay
Time frame: Up to 30 days
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Hospital General de Alicante
Alicante, Spain
Hospital Clínico Universitario San Carlos
Madrid, Spain
Hospital Comarcal de Axarquia
Málaga, Spain
Hospital General Universitario Reina Sofía
Murcia, Spain