A Study of Metyrapone and Oxazepam Combination Product (EMB-001) and Cocaine

Inclusion Criteria: * non-treatment-seeking cocaine users with a positive urine toxicology screen for cocaine at least once during screening * have a medical history and physical examination that demonstrate no clinically significant contraindication for participating in the study * males must use contraception; females must be of non-childbearing potential Exclusion Criteria: * drug allergies or reactions to metyrapone or benzodiazepines, or severe hypersensitivity reactions (like angioedema) to any drugs * history of clinically significant adverse reaction to cocaine * a low out-of-range serum cortisol value at screening or subjects who have a heightened likelihood of having adrenal insufficiency, or have signs or a history of adrenal insufficiency or confounders of the levels of cortisol and/or cortisol binding globulin * treatment with glucocorticoids * history of seizures, benzodiazepine use disorder, respiratory disease, neurologic or neuromuscular disease, liver disease or cardiovascular disease * other psychiatric or substance use disorders of clinical significance, or suicidality * clinically significant finding on medical history, physical examination, clinical laboratory tests, vital signs or ECGs * use of any other drugs * abnormal BP or HR * positive urine drug screen at for alcohol or any drug other than marijuana (THC) or cocaine * positive serology test results for HIV-1/HIV-2 Antibodies, Hepatitis B surface Antigen (HBsAg) or Hepatitis C Antibody (HCVAb)