The study aims to characterize the rhythmic parameters of unipolar depressed patients that are associated with the response to antidepressants after 6 weeks of treatment.
Patients are included at the time of their hospitalization in the psychiatry unit. They perform rhythmic parameters recording within 48hours after the initiation of the antidepressant treatment. An evaluation of the evaluation of the severity of depression symptoms is performed at 2, 4 and 6 weeks after the initiation of the antidepressant treatment. A correlation analysis will be performed with rhythmic parameters and the response to the antidepressant treatment.
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Purpose
OTHER
Masking
NONE
Enrollment
80
the following rhythmic parameters are recording during 48 hours: temperature, heart rate and actimetry
different psychometric scales are filled in: Montgomery and Asberg depression rating scale (MADRS), Quick inventory depression scale (QIDS-C16) and Beck depression inventory (BDI)
CHU Besancon
Besançon, Doubs, France
RECRUITINGsignificant difference of temperature amplitude between responder and non-responder
the response to the antidepressant treatment is determined by the variation of the MADRS score between pretreatment and 6 weeks of treatment. the complete response is obtained when the MADRS score has at least a 50% decrease after 6 weeks.
Time frame: 6 weeks
significant difference of activity duration between responder and non-responder
Time frame: 6 weeks
significant difference of RR interval of the heart rate between responder and non-responder
Time frame: 6 weeks
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