A Pilot Study of the Effects of Botulinum Toxin in the Treatment of Provoked Vestibulodynia

Inclusion Criteria: * Subject refractory to conventional treatments (tricyclic antidepressants and benzodiazepines at analgesic doses, biofeedback physical therapy) * Negative screening test results * Notified associated factors * Menopause, surgically sterilized women or women using effective contraceptive method * Good understanding and predictable adherence to the protocol * beneficiary/affiliated to French social security/social healthcare * signed Informed Consent Form Exclusion Criteria: * Predictable poor adherence * Pregnant or breastfeeding women * Myasthenia * Treatment with aminoglycosides * Major mental disorders * Underlying etiology * Vulnerable subjects (particularly adults under guardianship) * Any reason deemed relevant by the investigator * Current or former (in the last 3 months) participation to another clinical trial