The study aims to determine the correlation between the cognitive inhibition impairment and the history of suicide attempt in elderly depressed patients.
2 groups of patients will be studied: in the first group, depressed patients with a history of suicide attempt will be included whereas in the second group, depressed patients without a history of suicide attempt will be included. For each group, the cognitive inhibition will be assessed trough an eye tracker task (antisaccade). Both groups will also be compared on their neuropsychological characteristics and the quality of social interactions of participants.
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Purpose
SCREENING
Masking
NONE
Enrollment
36
several oculomotor parameters will be recorded using vide-oculography techniques (eye tracking) trough different tasks: saccade, antisaccade, and picture scanning. Saccade task: the patient is looking at a screen and is asked to fix his gaze as quickly and accurately as possible on the red dot appearing on the periphery of the screen. Prosaccade task: the patient is looking at a screen and is asked to fix his gaze as quickly and accurately as possible on the opposite side relative to the red dot appearing on the periphery of the screen. Picture Scanning: participant is instructed to freely watch pictures with different emotional valence.
the neuropsychological assessment aims to identify any impairment of executive functioning through several tasks: Mini mental state examination (mmse), isaac set test (STI) trail making test (TMT A and B), Grober test, Stroop test, verbal fluency, Go No Go task, memory impairment screen (MIS), picture naming test (DO30), copying figure test, digit span and categorical matching test.
CHU Besancon
Besançon, Doubs, France
RECRUITINGCHS Bavilliers
Bavilliers, France
NOT_YET_RECRUITINGantisaccade error rate
Time frame: 1 month max. after inclusion
saccade accuracy
distance between the eye position at the end of the first saccade, and the ideal position to engage the target in central vision
Time frame: 1 month max. after inclusion
saccadic intrusion
gaze deviation into a saccade greater than 3° during visual fixation
Time frame: 1 month max. after inclusion
maximal speed of the gaze
maximum speed of visual tracking without triggering any saccade
Time frame: 1 month max. after inclusion
saccade reaction time
Time frame: 1 month max. after inclusion
fixation duration on pictures
Time frame: 1 month max. after inclusion
social interaction quality score
Time frame: 6 month max. after inclusion
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.
this evaluation aims to characterize the mental status of the patient. Different scales will be used: Montgomery and ASberg depression rating scale (MADRS), Columbia-suicide severity rating scale (C-SSRS), Beck depression inventory (BDI), Barratt impulsiveness scale (BIS-10), Buss and Durkee Hostility Inventory (BDHI), Balloon, analogue risk task (BART), Iowa gambling task (IGT), and Childhood trauma questionnaire (CTQ).
this interview aims to characterize social interactions of the patients, their duration, their evolution and the perception of each participant on this subject.