Pronostic Value of Endothelial Dysfunction in Heart Failure

Centre Hospitalier Universitaire de Besancon7 enrolled

Overview

The main objective is to evaluate the pronostic value of endothelial dysfonction in acute heart failure on a combined criteria associating cardiovascular mortality, nex hospitalisation for decompensated heart failure, cardiac graft or ventricular assistance 2 month and 1 year before acute heart failure.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Heart Decompensation Cardiac Failure

Eligibility

Sex: ALLMin age: 18 YearsMax age: 81 Years

Medical Language ↔ Plain English

Inclusion Criteria: * patients hospitalized for acute heart fialure with Left Ventricular Ejection Fraction (LVEF) \< 45 % on echocardiography Exclusion Criteria: * Informed consent form not signed * Cardiogenic, septic or hemorragic shock * Acute coronary syndrom with elevated troponin * valvular surgery or aorto-coronary graft during next 3 months * Cancer * Pregnancy * life expectancy over than 1 year * chronic renal impairment

Outcomes

Primary Outcomes

MR Proadrenomedulline

Time frame: 6 months

catecholamins

Time frame: 6 months

late endothelial progenitors

Time frame: 6 months

Peripheral tissular perfusion

Near infra-red spectroscopy

Time frame: 6 months

mortality

Time frame: 6 months

hospitalisation

Time frame: 6 months

Data from ClinicalTrials.gov

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